Bhatt Neel S, Kelly Michael E, Batdorf Bjorn, Gheorghe Gabriela
Department of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin.
Department of Pathology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin.
Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26403. Epub 2016 Dec 30.
Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is frequently seen in this setting. However, CD30+ DLBCL with sinusoidal pattern of involvement has not been reported in pediatric PTLD. We are reporting a 9-year-old female child presented with diffuse lymphadenopathy postheart transplantation. The pattern of involvement was suggestive of anaplastic large cell lymphoma, but the malignant cells were positive for B-cell markers and negative for anaplastic lymphoma kinase. The patient was treated aggressively with multiagent chemotherapy and rituximab. Accurate diagnosis in PTLD is paramount in making management decisions.
