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妊娠相关血浆蛋白A：健康长寿的一个有前景的治疗靶点。

PAPP-A: a promising therapeutic target for healthy longevity.

作者信息

Conover Cheryl A, Oxvig Claus

机构信息

Endocrinology, Mayo Clinic, Rochester, MN, USA.

Department of Molecular Biology and Genetics, Aarhus Universitet, Aarhus, Denmark.

出版信息

Aging Cell. 2017 Apr;16(2):205-209. doi: 10.1111/acel.12564. Epub 2016 Dec 29.

DOI:10.1111/acel.12564
PMID:28035757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5334524/
Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity.

摘要

妊娠相关血浆蛋白-A（PAPP-A）是一种蛋白水解酶，它通过裂解抑制性胰岛素样生长因子结合蛋白（IGFBPs）来增加局部胰岛素样生长因子（IGF）的可利用性，从而激活受体。胰岛素样生长因子信号转导的减少与寿命和健康寿命的延长有关。因此，抑制PAPP-A代表了一种间接降低生物活性IGF可利用性的新方法。在这里，我们将综述支持PAPP-A作为促进健康长寿治疗靶点的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e2/5334524/5b0bb694ede8/ACEL-16-205-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e2/5334524/5b0bb694ede8/ACEL-16-205-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7e2/5334524/5b0bb694ede8/ACEL-16-205-g001.jpg

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