Shibata Tohru, Shinkura Satoshi, Ohnishi Atsushi, Ueda Kazuyoshi
Daicel Corporation, Life Science Development Center, Himeji 671-1283, Japan.
Graduate School of Engineering, Yokohama National University, Yokohama 240-8501, Japan.
Molecules. 2016 Dec 28;22(1):38. doi: 10.3390/molecules22010038.
Chromatographic separation of several sets of aromatic position isomers on three cellulose- and one amylose-based chiral stationary phases was performed to evaluate the potential of a polysaccharide-based chiral stationary phase (CSP) in the separation of isomeric or closely similar molecules, and to understand the interaction mechanism of this type of CSP with analytes. Their ability of molecular recognition was quite outstanding, but the selection rule was particular to each polysaccharide derivative. In the series of analytes, cellulose tris(4-methylbenzoate) and tris(3,5-dimethylphenylcarbamate) exhibited a contrasting selection rule, and the recognition mechanism was considered based on the computer-simulation of the former polymer.
在三种纤维素基和一种直链淀粉基手性固定相上对几组芳香族位置异构体进行了色谱分离，以评估多糖基手性固定相（CSP）在分离异构体或结构相近分子方面的潜力，并了解这类CSP与分析物的相互作用机制。它们的分子识别能力相当出色，但每种多糖衍生物的选择规则都很独特。在这一系列分析物中，三（4-甲基苯甲酸酯）纤维素和三（3,5-二甲基苯基氨基甲酸酯）表现出相反的选择规则，并基于对前一种聚合物的计算机模拟来考虑识别机制。
