Department of Operative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Institute of Epidemiology I, Helmholtz Zentrum Munich, German Research Centre for Environmental Health, Neuherberg, Munich, Germany.
J Clin Periodontol. 2017 Apr;44(4):372-381. doi: 10.1111/jcpe.12690. Epub 2017 Feb 11.
This cross-sectional study was repeated at two time points and investigated the influence of gingivitis, smoking and body mass index (BMI) on the systemic inflammatory markers high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL6) in 10- and 15-year-olds.
The study sample of two birth cohorts, i.e. GINIplus and LISAplus, from the Munich centre consisted of 806 and 846 subjects who were evaluated at 10- and 15-year follow-ups respectively. Children and their parents completed questionnaires on participant-related lifestyle information. Gingivitis was measured at the sextant level using a simplified sulcus-bleeding index. Serum hs-CRP and IL6 levels were obtained from blood samples. Multiple logistic regressions adjusting for lifestyle-related factors and other confounders were performed to assess associations between the specified variables.
There were no associations between gingivitis and the inflammatory markers hs-CRP and IL6 in 10-year-olds. In 15-year-olds, gingivitis (aOR: 2.17; 95% CI: 1.25-3.77); daily smoking (aOR: 6.27; 95% CI: 1.39-28.39); and being overweight/obese (aOR: 4.95; 95% CI: 0.73-33.68) were identified as significantly influencing factors for elevated hs-CRP values. Oral hygiene did not influence hs-CRP.
In this study, hs-CRP was positively associated with gingivitis, smoking daily and overweight/obesity among 15-year-olds.
本横断面研究在两个时间点重复进行，旨在调查牙龈炎、吸烟和体重指数（BMI）对 10 岁和 15 岁儿童系统炎症标志物高敏 C 反应蛋白（hs-CRP）和白细胞介素 6（IL6）的影响。
本研究的样本来自慕尼黑中心的两个出生队列，即 GINIplus 和 LISAplus，分别由 806 名和 846 名在 10 岁和 15 岁随访时评估的受试者组成。儿童及其父母完成了与生活方式相关的调查问卷。使用简化的龈沟出血指数在六分区水平上测量牙龈炎。从血液样本中获得血清 hs-CRP 和 IL6 水平。采用多元逻辑回归调整与生活方式相关的因素和其他混杂因素，以评估指定变量之间的关联。
在 10 岁儿童中，牙龈炎与炎症标志物 hs-CRP 和 IL6 之间没有关联。在 15 岁儿童中，牙龈炎（比值比：2.17；95%置信区间：1.25-3.77）；每日吸烟（比值比：6.27；95%置信区间：1.39-28.39）；超重/肥胖（比值比：4.95；95%置信区间：0.73-33.68）被确定为 hs-CRP 值升高的显著影响因素。口腔卫生对 hs-CRP 没有影响。
在这项研究中，hs-CRP 与 15 岁儿童的牙龈炎、每日吸烟和超重/肥胖呈正相关。
