Zhang Zhen-Zhen, Chen Qiang, Kong Chao-Yue, Li Zhan-Ming, Wang Li-Shun
Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
School of Public Health Taishan Medical University, Shandong, P.R. China.
Oncotarget. 2017 Jan 24;8(4):6623-6629. doi: 10.18632/oncotarget.14251.
Thyroid stimulating hormone receptor messenger RNA (TSHR-mRNA) is over-expressed in thyroid cancer patients, which indicates that TSHR-mRNA is a potential biomarker of thyroid cancer. However, system evaluation for TSHR-mRNA as a diagnostic biomarker of thyroid cancer is deficient. The performance of TSHR-mRNA for thyroid cancer diagnosis was evaluated in this study. Three common international databases as well as a Chinese database were applied for literature researching. Quality assessment of the included literatures was conducted by the QUADAS-2 tool. Totally, 1027 patients from nine studies eligible for the meta-analysis were included in this study. Global sensitivity and specificity for the positivity of TSHR-mRNA in the thyroid cancer diagnosis is 72% and 82%. The value of AUC for this test performance was 0.84. Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer. Notably, this findings need validation thorough large-scale clinical studies.
促甲状腺激素受体信使核糖核酸（TSHR-mRNA）在甲状腺癌患者中过度表达，这表明TSHR-mRNA是甲状腺癌的一个潜在生物标志物。然而，对TSHR-mRNA作为甲状腺癌诊断生物标志物的系统评估尚不足。本研究评估了TSHR-mRNA对甲状腺癌诊断的性能。应用三个常见的国际数据库以及一个中文数据库进行文献检索。采用QUADAS-2工具对纳入文献进行质量评估。本研究共纳入了来自9项符合荟萃分析条件研究的1027例患者。TSHR-mRNA阳性在甲状腺癌诊断中的总体敏感性和特异性分别为72%和82%。该检测性能的AUC值为0.84。我们的荟萃分析表明，TSHR-mRNA可能是一种潜在的生物标志物，可完善目前甲状腺癌早期精准诊断的诊断方法。值得注意的是，这一发现需要通过大规模临床研究进行验证。
