Yao Kun-Fang, Ma Ming, Ding Guo-Yong, Li Zhan-Ming, Chen Hui-Ling, Han Bing, Chen Qiang, Jiang Xin-Quan, Wang Li-Shun
Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, P.R. China.
School of Public Health Taishan Medical University, Shandong, P.R. China.
Oncotarget. 2017 Aug 10;8(42):72959-72971. doi: 10.18632/oncotarget.20127. eCollection 2017 Sep 22.
Excess body weight has a positive association with risk of liver cancer, but the gender difference in the relationship between body mass index and liver cancer risk remains uncertainty. In this work, we performed meta-analysis for excess body weight and risk of liver cancer incidence to identify the gender difference. We searched the English-languages database and the Chinese literature databases to May 12, 2017. Overall, a total of 17 studies were included. Relative risks (RRs) with 95% confidence intervals was used to evaluate the strength of these associations. The RRs of liver cancer incidence for obese men and women were 2.04 (1.70-2.44) and 1.56 (1.37-1.78). The former one was significantly higher than the later one (P for interaction = 0.02). Notably, the RR of liver cancer incidence in non-Asian obese men was even higher than their counter part (2.31(1.85-2.91) vs. 1.56 (1.31-1.86), P for interaction = 0.01). Similar gender difference was observed in the dose-response curve. As example, at the point of BMI = 32 kg/m, the RRs for men and women were 1.61 (1.45-1.79) and 1.41 (1.02-1.94) respectively. Findings from this meta-analysis indicate that obesity is associated with a higher risk of liver cancer incidence in men, especially in non-Asian men, which might partially contribute to the male dominance of liver cancer incidence.
超重与肝癌风险呈正相关，但体重指数与肝癌风险之间关系的性别差异仍不明确。在本研究中，我们对超重与肝癌发病风险进行了荟萃分析，以确定性别差异。我们检索了英文数据库和中文文献数据库，检索截止至2017年5月12日。总体而言，共纳入17项研究。采用95%置信区间的相对风险（RR）来评估这些关联的强度。肥胖男性和女性肝癌发病的RR分别为2.04（1.70 - 2.44）和1.56（1.37 - 1.78）。前者显著高于后者（交互作用P值 = 0.02）。值得注意的是，非亚洲肥胖男性肝癌发病的RR甚至高于其对应人群（2.31(1.85 - 2.91) 对 1.56 (1.31 - 1.86)，交互作用P值 = 0.01）。在剂量反应曲线中也观察到了类似的性别差异。例如，在BMI = 32 kg/m这一点上，男性和女性的RR分别为1.61（1.45 - 1.79）和1.41（1.02 - 1.94）。这项荟萃分析的结果表明，肥胖与男性尤其是非亚洲男性肝癌发病风险较高相关，这可能部分解释了肝癌发病中男性占主导的现象。
