西氯他宁急性和亚慢性治疗对大鼠DOCA-盐高血压的影响。
The effect of acute and subchronic treatment with cicletanine on DOCA-salt hypertension in the rat.
作者信息
Fuentes J A, Castro A, Alsasua A
机构信息
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
出版信息
Am J Hypertens. 1989 Sep;2(9):718-20. doi: 10.1093/ajh/2.9.718.
PMID:2803677
Abstract
Cicletanine, a new furopyridine derivative synthetized by the Institut Henri Beaufour (France) was found to work as an efficient antihypertensive agent in DOCA-salt rats. This compound also inhibited the development of cardiac hypertrophy characteristic of this sort of hypertension. The mechanism of antihypertensive action at nondiuretic doses of cicletanine remains to be studied.
摘要
西氯他宁是法国亨利·博福公司合成的一种新型呋吡啶衍生物，在去氧皮质酮盐性高血压大鼠中被发现是一种有效的抗高血压药物。该化合物还抑制了这种高血压特有的心脏肥大的发展。西氯他宁非利尿剂量的抗高血压作用机制仍有待研究。
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