Malherbe E, Le Hegarat M, Clostre F, Braquet P
Henri Beaufour Institute, Le Plessis-Robinson, France.
Drugs Exp Clin Res. 1988;14(2-3):83-8.
The effects of cicletanine were compared with those of four other antihypertensive drugs (prazosin, a highly selective alpha 1 antagonist; captopril, an angiotensin-converting enzyme inhibitor; indapamide, an antihypertensive diuretic; and hydrochlorothiazide, a purely diuretic agent) on young stroke-prone SHR rats with high-salt diet. All the drugs except hydrochlorothiazide prevented the onset of hypertension. The minimal effective dose on blood pressure was 1 mg/kg for both cicletanine and captopril, and 3 mg/kg for indapamide. The action on cardiac hypertrophy and diuresis occurs at a dose of cicletanine 10 to 30 times higher than that required to produce the antihypertensive effect. Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg.
在高盐饮食的年轻易中风自发性高血压大鼠（SHR）中，将西氯他宁的作用与其他四种抗高血压药物（哌唑嗪，一种高选择性α1拮抗剂；卡托普利，一种血管紧张素转换酶抑制剂；吲达帕胺，一种抗高血压利尿剂；氢氯噻嗪，一种单纯的利尿剂）进行了比较。除氢氯噻嗪外，所有药物均能预防高血压的发生。西氯他宁和卡托普利对血压的最小有效剂量均为1mg/kg，吲达帕胺为3mg/kg。西氯他宁产生抗高血压作用的剂量比其产生心脏肥大和利尿作用的剂量低10至30倍。西氯他宁100mg/kg的剂量也能显著降低肾脏肥大。
