Close L G, Brown P M, Vuitch M F, Reisch J, Schaefer S D
Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035.
Arch Otolaryngol Head Neck Surg. 1989 Nov;115(11):1304-9. doi: 10.1001/archotol.1989.01860350038011.
Although the presence of squamous cell carcinoma within the peritumoral vascular spaces of primary lesions of the oral cavity and oropharynx has been statistically linked to regional lymph node metastases, the association of this finding with disease control and survival has not been well demonstrated. To evaluate this relationship, we have reviewed the clinical and histopathologic features of 65 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed by simultaneous surgical treatment of the primary lesion and regional lymph nodes. Of all the histopathologic features of the primary lesion studied, vascular invasion had the greatest impact on survival, as confirmed by both univariate and multivariate analysis. In addition, vascular invasion correlated statistically with local recurrence, neck recurrence, and distant metastasis.
尽管口腔和口咽原发性病变的瘤周血管间隙内存在鳞状细胞癌在统计学上与区域淋巴结转移相关，但这一发现与疾病控制和生存的关联尚未得到充分证实。为了评估这种关系，我们回顾了65例连续的这些部位先前未经治疗的T2期或更高级别的鳞状细胞癌病例的临床和组织病理学特征，这些病例采用了对原发性病变和区域淋巴结同时进行手术治疗的方法。在研究的原发性病变的所有组织病理学特征中，血管侵犯对生存的影响最大，单因素和多因素分析均证实了这一点。此外，血管侵犯在统计学上与局部复发、颈部复发和远处转移相关。
