Nara T, Goto N, Nozaki H, Maekawa K
No To Hattatsu. 1989 Sep;21(5):453-9.
The development of the human facial nucleus was studied using complete serial sections of the brains of 8 fetuses at 21, 23, 27, 30, 33, 34, 35, and 40 weeks of gestation, a 2-month-old infant and a 63-year-old adult. Morphometric analysis adopting a microscope, an electronic planimeter and a computer revealed the following three points as to the development of the human facial nucleus. (1) The size of neurons, the amount of Nissl body, the length of processes and neuropil increased gradually after 30 weeks of gestation. (2) The facial nucleus was divided cytoarchitectonically into dorsal, medial, intermediate, ventromedial, ventrolateral and lateral subnuclei at 21 weeks of gestation onwards. The mean neuronal size of the medial subnucleus was smaller than that of other subnuclei. (3) The number of neurons was practically the same regardless of age. At 21 and 33 weeks of gestation, 10% of total neurons was degenerated.
利用妊娠21、23、27、30、33、34、35和40周的8例胎儿、1例2个月大婴儿及1例63岁成人的完整系列脑切片，对人类面神经核的发育进行了研究。采用显微镜、电子求积仪和计算机进行形态计量学分析，揭示了人类面神经核发育的以下三点情况。（1）妊娠30周后，神经元大小、尼氏体数量、突起长度和神经毡逐渐增加。（2）妊娠21周起，面神经核在细胞构筑上可分为背侧、内侧、中间、腹内侧、腹外侧和外侧亚核。内侧亚核的平均神经元大小小于其他亚核。（3）神经元数量实际上与年龄无关。在妊娠21周和33周时，10%的神经元发生退化。
