Nara T, Goto N, Yamaguchi K
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
Dev Neurosci. 1989;11(3):212-20. doi: 10.1159/000111900.
Development of the human hypoglossal nucleus was studied using complete serial sections of the brains of 9 fetuses at 16, 18, 21, 23, 27, 32, 33, 35 and 40 weeks of gestation, a 2-month-old infant, a 16-year-old adolescent and a 63-year-old adult. Morphometric analysis produced the following three findings pertaining to the development of the human hypoglossal nucleus: (1) development may accelerate after 32 weeks of gestation; (2) postnatal maturation is observable, and (3) natural cell death, as indicated by a decrease in the number of neurons and the appearance of degenerating neurons, may occur during fetal development.
利用9例分别处于妊娠16、18、21、23、27、32、33、35和40周的胎儿、1例2个月大的婴儿、1例16岁青少年以及1例63岁成年人的完整连续脑切片，对人类舌下神经核的发育进行了研究。形态计量分析得出了与人类舌下神经核发育相关的以下三个结果：（1）妊娠32周后发育可能加速；（2）出生后成熟是可观察到的，以及（3）如神经元数量减少和退化神经元出现所示的自然细胞死亡可能在胎儿发育期间发生。
