Touho H, Karasawa J, Shishido H, Yamada K, Yamazaki Y, Asai M, Kawabata K, Kobayashi K, Kitamura T, Kagawa M
Department of Neurosurgery, Osaka Neurological Institute, Tayonaka, Japan.
No To Shinkei. 1989 Jun;41(6):603-9.
Non-invasive methods with monitoring end-tidal stable xenon (ETXes) are described for estimating local cerebral blood flow (LCBF) and local partition coefficient (L lambda). 30% of Xes in oxygen was inhaled for 240 sec and exhaled for 160 sec during serial CT scannings after denitrogenation with pure oxygen breathing. During the examination, serial samplings of arterial blood and continuous monitoring of ETXes were performed to determine build up range (A) and build up rate constant (K) of artery. Calculated A and K using the arterial sampling (Aa and Ka, respectively) were compared with the calculated A and K using the continuous monitoring of ETXes (Ae and Ke, respectively) in 109 patients with epilepsy, head trauma, or cerebrovascular diseases. Ae and Ke had significantly positive correlation with Aa and Ka, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
描述了用于估计局部脑血流量（LCBF）和局部分配系数（Lλ）的监测终末潮气稳定氙（ETXes）的非侵入性方法。在用纯氧呼吸进行去氮后，在连续CT扫描期间，吸入含30%氙的氧气240秒，然后呼出160秒。在检查过程中，进行动脉血的连续采样和ETXes的连续监测，以确定动脉的蓄积范围（A）和蓄积速率常数（K）。将使用动脉采样计算的A和K（分别为Aa和Ka）与使用ETXes连续监测计算的A和K（分别为Ae和Ke）在109例癫痫、头部创伤或脑血管疾病患者中进行比较。Ae和Ke分别与Aa和Ka有显著正相关。（摘要截断于250字）
