Sase S
Anzai Medical Corporation, Tokyo, Japan.
J Comput Assist Tomogr. 1998 Sep-Oct;22(5):786-91. doi: 10.1097/00004728-199809000-00022.
The purpose of this work is to show how variations in inhalation speed of xenon gas affect cerebral blood flow (CBF) values obtained using the end-tidal method on xenon-enhanced CT (Xe-CT). We tried to clarify whether arterial xenon concentration could keep up with end-tidal xenon concentration by evaluating the effect of xenon inhalation speed on calculated CBF values.
The same subject underwent two or three consecutive Xe-CT examinations, varying xenon inhalation speed. The rate constants of applied inhalation speeds were 0.1-0.15 min-1 (low speed), 0.25-0.3 min-1 (middle speed), and 1-2 min-1 (high speed), respectively.
No significant difference was observed among the CBF values of the same subject obtained under different inhalation speeds.
End-tidal xenon can closely reflect arterial xenon under the customary method of xenon supply. The end-tidal method can provide reliable absolute CBF values, assuming actual CBF values are substantially unchanged regardless of the inhalation speed variation applied in this work.
本研究旨在展示氙气吸入速度的变化如何影响在氙增强CT（Xe-CT）上使用终末潮气法获得的脑血流量（CBF）值。我们试图通过评估氙气吸入速度对计算得到的CBF值的影响，来阐明动脉血氙浓度是否能跟上终末潮气氙浓度。
同一受试者连续进行两到三次Xe-CT检查，改变氙气吸入速度。应用的吸入速度的速率常数分别为0.1 - 0.15 min⁻¹（低速）、0.25 - 0.3 min⁻¹（中速）和1 - 2 min⁻¹（高速）。
在不同吸入速度下获得的同一受试者的CBF值之间未观察到显著差异。
在常规的氙气供应方法下，终末潮气氙能密切反映动脉血氙。假设在本研究中应用的吸入速度变化不影响实际CBF值，终末潮气法可提供可靠的绝对CBF值。
