Institution and Department, Bakırköy Research & Training Hospital for Psychiatry, Neurology and Neurosurgery/Psychiatry Services, Turkey.
Institution and Department, Gaziantep Ersin Arslan Hospital/Psychiatry Services, Turkey.
Psychiatry Res. 2017 Feb;248:105-110. doi: 10.1016/j.psychres.2016.12.027. Epub 2016 Dec 21.
Executive functions meet the "endophenotype candidate" criteria in neuropsychological measures for schizophrenic patients. To determine which area of executive functioning has the greatest value in differentiating the so called "candidate endophenotype" of schizophrenia through comparing the effect sizes of four commonly used executive function tests. A Wisconsin Card Sorting Test, a Stroop Test, a Trail Making Test and a Verbal Fluency Test were used to evaluate executive function in two study groups: healthy relatives of schizophrenia patients from simplex and multiplex families and a healthy control group. In all four tests, study groups performed poorly in contrast to the control group. In the B time, A error and B error results of the Trail Making Test, the multiplex group performed poorly compared to the simplex group; control group did better than both study groups. Our findings support that the presence of a schizophrenia patient in a family predicts worse performance on executive function tests in a group of healthy relatives of that individual. The results of our study suggest that the Trail Making Test in particular may signify a stronger endophenotypic trait.
执行功能符合精神分裂症患者神经心理学测量的“候选内表型”标准。通过比较四种常用执行功能测试的效应大小，确定在区分所谓的“候选内表型”方面，哪个执行功能区域具有最大的价值。威斯康星卡片分类测试、斯特鲁普测试、连线测试和言语流畅性测试用于评估来自单发性和多发性家庭的精神分裂症患者的健康亲属和健康对照组的执行功能。在所有四项测试中，与对照组相比，研究组的表现都较差。在连线测试的 B 时间、A 错误和 B 错误结果中，多发性组的表现比单发性组差；对照组比两个研究组都要好。我们的发现支持这样一种观点，即一个家庭中有精神分裂症患者，这预示着该个体的一群健康亲属在执行功能测试中的表现更差。我们的研究结果表明，特别是连线测试可能具有更强的内表型特征。
