Suppr超能文献

20世纪30年代至50年代可的松发现、合成及生产的一些社会层面情况。

Some social aspects of discovery, synthesis and production of cortisone in the 1930s-1950s.

作者信息

Jadreškić Daria

机构信息

Department of Philosophy, Faculty of Humanities and Social Sciences, University of Rijeka, Rijeka, Croatia.

出版信息

Acta Med Hist Adriat. 2016 Dec;14(2):333-346.

Abstract

A discovery, synthesis and therapeutic application of cortisone present a paradigm for modern translational medicine (Hillier 2007, Saenger 2010), since they represented a joint achievement of discoveries by biochemists, Edward Calvin Kendall and Tadeus Reichstein; large scale synthesis by an industrial chemist, Lewis Hastings Sarett, and therapeutic application by a rheumatologist, Philip Showalter Hench. The goal of translational medicine is to speed up the process between basic research and clinical practice, and to integrate multiple disciplines in order to understand diverse outcomes (Zhang et al. 2014). In this paper conditions that made this basic/applied/clinical research interface possible will be presented: the rise of steroid chemistry, simultaneous individual accomplishments as well as continuous cooperation among scientists, military competitiveness, and cooperation among pharmaceutical companies.

摘要

可的松的发现、合成及治疗应用为现代转化医学树立了一个典范(希利尔,2007年;森格尔,2010年),因为它们代表了生物化学家爱德华·卡尔文·肯德尔和塔德乌什·赖希施泰因的发现成果、工业化学家刘易斯·黑斯廷斯·萨雷特的大规模合成以及风湿病学家菲利普·肖沃尔特·亨奇的治疗应用。转化医学的目标是加快基础研究与临床实践之间的进程,并整合多学科以了解不同结果(张等人,2014年)。本文将介绍使这种基础/应用/临床研究界面成为可能的条件:甾体化学的兴起、科学家们同时取得的个人成就以及持续合作、军事竞争力以及制药公司之间的合作。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验