Rambo Cassiano L, Mocelin Ricieri, Marcon Matheus, Villanova Débora, Koakoski Gessi, de Abreu Murilo S, Oliveira Thiago A, Barcellos Leonardo J G, Piato Angelo L, Bonan Carla D
PUCRS, Programa de Pós-Graduação em Biologia Celular e Molecular, Laboratório de Neuroquímica e Psicofarmacologia, Av. Ipiranga, 6681, 90619-900 Porto Alegre, RS, Brazil.
Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Neurociências, Laboratório de Psicofarmacologia e Comportamento, Av. Sarmento Leite 500/107, 90050-170 Porto Alegre, RS, Brazil.
Physiol Behav. 2017 Mar 15;171:50-54. doi: 10.1016/j.physbeh.2016.12.032. Epub 2016 Dec 28.
Chronic stress may cause physical, behavioral and neuropsychiatric changes, affecting the health condition of an individual. Aggression is a universal behavior with great relevance on human and animal social systems. Despite studies showing the influence of chronic stress on aggression, the effects of unpredictable chronic stress (UCS) on aggressive behavior in male and female zebrafish remain unknown. Thus, the aim of this study was to evaluate the effects of UCS on the aggressive behavior and cortisol levels in adult zebrafish of both sexes. Our results showed that UCS increased aggression in males, but not in females, which displayed more aggressive behavior at baseline than control males. Increased whole-body cortisol levels were observed in stressed males; however, no differences were found between female groups. In conclusion, we reported for the first time gender differences on behavioral parameters and cortisol levels in response to UCS in zebrafish. These results highlight the relevance of studying behavioral and physiological parameters in both sexes separately.
慢性应激可能会导致身体、行为和神经精神方面的变化，影响个体的健康状况。攻击行为是一种普遍存在的行为，对人类和动物的社会系统具有重要意义。尽管有研究表明慢性应激会对攻击行为产生影响，但不可预测的慢性应激（UCS）对雄性和雌性斑马鱼攻击行为的影响仍不清楚。因此，本研究的目的是评估UCS对成年雌雄斑马鱼攻击行为和皮质醇水平的影响。我们的结果表明，UCS增加了雄性的攻击性，但对雌性没有影响，雌性在基线时比对照雄性表现出更多的攻击行为。在应激雄性中观察到全身皮质醇水平升高；然而，雌性组之间没有发现差异。总之，我们首次报道了斑马鱼对UCS反应的行为参数和皮质醇水平存在性别差异。这些结果突出了分别研究两性行为和生理参数的重要性。
