Keeling A A, Vaughan A T, Beaney R P
Department of Immunology, University of Birmingham, UK.
Br J Cancer. 1989 Jul;60(1):74-8. doi: 10.1038/bjc.1989.223.
Yttrium-90 chelated by the tetraphosphonate EDTMP achieved a high uptake in bone and a rapid clearance from all soft tissues compared with 90Y nitrilotriacetate, citrate and acetate. The biological half-life of 90Y in the bone was greater than 72 h, but the quantity, and therefore dose, could be reduced by 50% using repeated, non-toxic chelation therapy with the calcium salt of DTPA. This treatment should be able to supplement current treatments for leukaemia where the dose of external beam radiation is associated with considerable morbidity.
与钇-90亚氨基三乙酸、柠檬酸盐和醋酸盐相比，四膦酸盐依替膦酸二钠螯合的钇-90在骨骼中摄取量高，且能从所有软组织中快速清除。钇-90在骨骼中的生物半衰期大于72小时，但使用无毒的二乙三胺五乙酸钙盐进行重复螯合治疗，其含量进而剂量可降低50%。这种治疗应该能够补充目前白血病的治疗方法，因为外照射剂量会带来相当大的发病率。
