Beyer G J, Bergmann R, Kampf G, Mäding P, Rösch F
Central Institute of Nuclear Research, Rossendorf, RI Department, Dresden, Fed. Rep. Germany.
Int J Rad Appl Instrum B. 1992 Feb;19(2):201-3. doi: 10.1016/0883-2897(92)90008-m.
The influence of the ligands ethylenediaminetetramethylene phosphonic acid (EDTMP) and citrate (CIT) on the biodistribution of radio-yttrium in rats bearing a DS-carcinosarcoma was compared. 88Y-EDTMP and 87Y-CIT were i.v. injected into the same animals. Faster blood clearance and higher renal excretion were observed for the EDTMP-ligand. Of high practical interest is the reduced liver uptake of radio-yttrium (by one order of magnitude) with the EDTMP complex. Since bone and tumour accumulation is only weakly influenced, high tumour-to-liver ratios (up to 14) were observed. We propose to use EDTMP or similar complex ligands for liver blocking when radionuclides like 90Y, 169Yb, 225Ac or other group 3 elements are to be applied in endoradionuclide therapy technique.
比较了配体乙二胺四亚甲基膦酸（EDTMP）和柠檬酸盐（CIT）对携带DS-癌肉瘤大鼠体内放射性钇生物分布的影响。将88Y-EDTMP和87Y-CIT静脉注射到同一组动物体内。观察到EDTMP配体的血液清除更快，肾脏排泄更高。具有高度实际意义的是，EDTMP复合物使肝脏对放射性钇的摄取减少（降低了一个数量级）。由于骨和肿瘤的蓄积仅受到微弱影响，因此观察到高的肿瘤与肝脏摄取比（高达14）。我们建议，当在核素内照射治疗技术中应用如90Y、169Yb、225Ac或其他第3族元素等放射性核素时，使用EDTMP或类似的复合配体进行肝脏阻断。
