Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Br J Anaesth. 2017 Jan;118(1):44-57. doi: 10.1093/bja/aew312.
This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.
这篇综述描述了药物动力学和药效学药物相互作用的基础知识，以及在设计药物相互作用研究时特别关注的方法学要点。它还概述了有关相互作用的可用文献，重点介绍了使用等效应线和响应面模型来表示相互作用的图形表示方法。它举例说明了如何将这些知识转化为临床和教育上适用的（床边）工具。
