Koupenova Milka, Kehrel Beate E, Corkrey Heather A, Freedman Jane E
University of Massachusetts Medical School, Albert Sherman Center, 368 Plantation St, Worcester, MA 01605, USA.
Westfälische Wilhelms University Muenster, Münster, University Hospital, Department of Anaesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Haemostasis Research, D-48149 Muenster, Germany Mendelstrasse 11, UK.
Eur Heart J. 2017 Mar 14;38(11):785-791. doi: 10.1093/eurheartj/ehw550.
Haemostasis and thrombosis are complex, multifactorial processes. There is an evolving understanding of the mechanisms influencing vascular occlusion and the role of inflammation and immunity. Despite major advances in elucidating the mechanistic pathways mediating platelet function and thrombosis, challenges in the treatment of vascular occlusive diseases persist. Pharmacological advances have greatly affected thrombotic outcomes, but this has led to the unwanted side effect of bleeding. Detailed assessment of the impact of non-thrombotic diseases on haemostasis and thrombosis is necessary to better evaluate thrombotic risk and establish optimal treatment. This review will focus on recent advances in understanding the contribution of evolving risk factors to thrombosis.
止血和血栓形成是复杂的多因素过程。人们对影响血管闭塞的机制以及炎症和免疫的作用的认识正在不断发展。尽管在阐明介导血小板功能和血栓形成的机制途径方面取得了重大进展，但血管闭塞性疾病的治疗挑战依然存在。药理学进展极大地影响了血栓形成的结果，但这也导致了出血这一不良副作用。详细评估非血栓性疾病对止血和血栓形成的影响对于更好地评估血栓形成风险和确立最佳治疗方法很有必要。本综述将聚焦于在理解不断变化的风险因素对血栓形成的影响方面的最新进展。
