甘油三酯-葡萄糖指数与高血压患者冠心病的患病率及严重程度呈正相关。

The triglyceride-glucose index positively associates with the prevalence and severity of coronary heart disease in patients among hypertension.

作者信息

Wu Lingling, Bao Xue, Xu Ji, Ma Lingyu, Kang Lina, Zhang Ronglin

机构信息

Department of Cardiology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, Jiangsu, China.

Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210093, China.

出版信息

Sci Rep. 2025 Jun 4;15(1):19571. doi: 10.1038/s41598-025-03948-y.

DOI:10.1038/s41598-025-03948-y

PMID:40467641

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137601/

Abstract

Insulin resistance (IR) links hypertension (HTN) and coronary heart disease (CHD). This study investigated the link between the triglyceride-glucose (TyG) index, a marker for detecting IR, and the prevalence and severity of CHD in patients with HTN. Limited evidence exists on this relationship. This cross-sectional study included 1,432 hospitalized patients with HTN who underwent coronary angiography between January 1, 2019, and December 31, 2023. The study cohort was predominantly male, with a median age of 65 years. Common comorbidities included type 2 diabetes mellitus, smoking history, and alcohol consumption. Patients were excluded if they lacked complete clinical data, had a history of coronary artery bypass grafting (CABG) or other severe heart diseases, or had malignant tumors, acute or chronic infections, severe cerebrovascular disease, end-stage renal disease, or severe hepatic dysfunction. Multivariate logistic regression analysis was used to assess the association between the TyG index and the prevalence of CHD. The TyG index was categorized into tertiles and also treated as a continuous variable in the analysis. Among HTN-CHD groups, the relationship between the Gensini score (GS), an indicator of CHD severity, and the TyG index was assessed using multivariate linear regression analysis. After adjusting for confounding variables, multivariate logistic regression analysis indicated that compared to tertile 1 of the TyG index, the odds ratio for the prevalence of CHD in patients with TyG index in tertile 2 was 2.01 (95% CI, 1.47-2.73; p < 0.001), and in tertile 3 was 3.86 (95% CI, 2.71-5.50; p < 0.001). Additionally, a raised positive correlation was shown by multivariate linear regression analysis between the GS and the TyG index. In the HTN-CHD group, each 1-unit increase in the TyG index was associated with a 16.777 increase in the GS (β = 16.777; 95% CI, 13.81-19.74; p < 0.001).

摘要

胰岛素抵抗（IR）与高血压（HTN）和冠心病（CHD）相关。本研究调查了用于检测IR的甘油三酯-葡萄糖（TyG）指数与HTN患者CHD患病率及严重程度之间的关联。关于这种关系的证据有限。这项横断面研究纳入了2019年1月1日至2023年12月31日期间接受冠状动脉造影的1432例住院HTN患者。研究队列以男性为主，中位年龄为65岁。常见合并症包括2型糖尿病、吸烟史和饮酒史。若患者缺乏完整临床数据、有冠状动脉旁路移植术（CABG）史或其他严重心脏病史、或患有恶性肿瘤、急慢性感染、严重脑血管疾病、终末期肾病或严重肝功能不全，则被排除。采用多因素logistic回归分析评估TyG指数与CHD患病率之间的关联。TyG指数被分为三分位数，并在分析中也作为连续变量处理。在HTN-CHD组中，使用多因素线性回归分析评估冠心病严重程度指标Gensini评分（GS）与TyG指数之间的关系。在调整混杂变量后，多因素logistic回归分析表明，与TyG指数三分位数1相比，TyG指数三分位数2的患者CHD患病率的比值比为2.01（95%CI，1.47 - 2.73；p < 0.001），三分位数3为3.86（95%CI，2.71 - 5.50；p < 0.001）。此外，多因素线性回归分析显示GS与TyG指数之间呈显著正相关。在HTN-CHD组中，TyG指数每增加1个单位，GS增加16.77（β = 16.77；95%CI，13.81 - 19.74；p < 0.001）。