Müller Ivan, Beyleveld Lindsey, Gerber Markus, Pühse Uwe, du Randt Rosa, Utzinger Jürg, Zondie Leyli, Walter Cheryl, Steinmann Peter
Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland.
University of Basel, P.O. Box, CH-4003 Basel, Switzerland.
Trans R Soc Trop Med Hyg. 2016 Nov;110(11):676-678. doi: 10.1093/trstmh/trw075. Epub 2016 Dec 29.
Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis.
A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg).
Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%).
Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.
阿苯达唑是控制土源性蠕虫病的两种标准药物之一。
在南非伊丽莎白港，对149名学童在服用阿苯达唑（400毫克）之前和之后2周，使用双份Kato-Katz厚涂片检查土源性蠕虫感染情况。
Trichuris trichiura是主要的土源性蠕虫种类（感染率60.4%），其次是蛔虫（47.7%）。虽然阿苯达唑对蛔虫高度有效（治愈率[CR]97.2%；虫卵减少率[ERR]94.3%），但对Trichuris trichiura缺乏疗效（CR 1.1%；ERR 46.0%）。
我们的研究证实单剂量阿苯达唑对Trichuris trichiura疗效较低。需要有针对Trichuris trichiura的安全有效的药物。
