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卢旺达西部开展十年预防性化疗后学童土壤传播蠕虫感染的流行率、感染强度及相关因素

Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda.

作者信息

Kabatende Joseph, Mugisha Michael, Ntirenganya Lazare, Barry Abbie, Ruberanziza Eugene, Mbonigaba Jean Bosco, Bergman Ulf, Bienvenu Emile, Aklillu Eleni

机构信息

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge,14186 Stockholm, Sweden.

Rwanda Food and Drugs Authority, Nyarutarama Plaza, KG 9 Avenue Kigali, Rwanda.

出版信息

Pathogens. 2020 Dec 21;9(12):1076. doi: 10.3390/pathogens9121076.

Abstract

Preventive chemotherapy (PC) is a WHO-recommended core intervention measures to eliminate Soil-Transmitted Helminths (STH) as a public health problem by 2020, defined as a reduction in prevalence to <1% of moderate or high-intensity infection. We conducted a cross-sectional study to investigate the prevalence, intensity, and correlates of STH after a decade of PC in Rwanda. A total of 4998 school children (5-15 years old) from four districts along Lake Kivu in the western province were screened for STH using Kato-Katz. The overall prevalence of Soil-transmitted helminths among school children was 77.7% (range between districts = 54% to 92%). was the most common STH (66.8%, range between districts = 23% to 88.2%), followed by (49.9%, range between district = 28.5% to 63.3%) and hookworms (1.9%, range between districts = 0.6% to 2.9%). The prevalence of single, double and of triple parasite coinfection were 48.6%, 50.3%, and 1.1%, respectively. The overall prevalence of moderate or high-intensity infection for and was 7.1% and 13.9, respectively. Multivariate logistic regression model revealed that male sex, district, stunting, and schistosomiasis coinfection as significant predictors of STH infection. Despite a decade of PC implementation, STH remain a significant public health problem in Rwanda.

摘要

预防性化疗(PC)是世界卫生组织推荐的一项核心干预措施,旨在到2020年消除作为公共卫生问题的土壤传播蠕虫(STH),其定义为将中度或高强度感染的患病率降至<1%。我们开展了一项横断面研究,以调查卢旺达实施十年预防性化疗后土壤传播蠕虫的患病率、感染强度及其相关因素。使用加藤厚涂片法对西部省份基伍湖沿岸四个地区的4998名学童(5至15岁)进行了土壤传播蠕虫筛查。学童中土壤传播蠕虫的总体患病率为77.7%(各地区范围为54%至92%)。蛔虫是最常见的土壤传播蠕虫(66.8%,各地区范围为23%至88.2%),其次是鞭虫(49.9%,各地区范围为28.5%至63.3%)和钩虫(1.9%,各地区范围为0.6%至2.9%)。单一寄生虫感染、双重寄生虫感染和三重寄生虫感染的患病率分别为48.6%、50.3%和1.1%。蛔虫和鞭虫中度或高强度感染的总体患病率分别为7.1%和13.9%。多变量逻辑回归模型显示,男性、地区、发育迟缓以及合并血吸虫感染是土壤传播蠕虫感染的重要预测因素。尽管实施了十年的预防性化疗,但土壤传播蠕虫在卢旺达仍然是一个重大的公共卫生问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d76/7767502/1943c7e44535/pathogens-09-01076-g001.jpg

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