癌性乳腺非恶性部分中的表皮生长因子受体和雌激素受体。
Epidermal growth factor receptor and oestrogen receptors in the non-malignant part of the cancerous breast.
作者信息
Barker S, Panahy C, Puddefoot J R, Goode A W, Vinson G P
机构信息
Department of Biochemistry, Medical College of St Bartholomew's Hospital, London, UK.
出版信息
Br J Cancer. 1989 Nov;60(5):673-7. doi: 10.1038/bjc.1989.338.
Abstract
Fifty-one samples of non-malignant tissue from four mastectomies were analysed to assess oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) status across the cancerous breast. No significant relationship was found between the presence of EGFR and ER. Eighty-four per cent of these samples were EGFR positive and 29% expressed both receptor types. EGFR and ER expression was not affected by histological sub-group. In contrast, analysis of 44 primary cancers showed, in agreement with the literature, a significant inverse relationship between the presence of ER and EGFR (Fisher's exact test P less than 0.002). The difference between malignant and non-malignant tissue appeared to result from the prevalence of co-expression of EGFR and ER in the non-malignant specimens. This suggests different regulation of receptor expression in malignant and non-malignant tissue.
摘要
对来自4例乳房切除术的51份非恶性组织样本进行分析，以评估癌性乳腺组织中雌激素受体（ER）和表皮生长因子受体（EGFR）的状态。未发现EGFR的存在与ER之间存在显著关系。这些样本中84%为EGFR阳性，29%同时表达两种受体类型。EGFR和ER的表达不受组织学亚组的影响。相比之下，对44例原发性癌症的分析表明，与文献一致，ER的存在与EGFR之间存在显著的负相关（Fisher精确检验P<0.002）。恶性组织与非恶性组织之间的差异似乎是由于非恶性标本中EGFR和ER共表达的普遍性所致。这表明恶性组织和非恶性组织中受体表达的调控不同。
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