Otter R, Bieger R, Kluin P M, Hermans J, Willemze R
Comphrensive Cancer Centre West, Leiden, The Netherlands.
Br J Cancer. 1989 Nov;60(5):745-50. doi: 10.1038/bjc.1989.351.
In a population-based registry of 580 patients with non-Hodgkin's lymphoma (NHL) 54 patients had a primary gastric lymphoma, 42 an intestinal, 113 a primary extranodal lymphoma localised elsewhere than in the gastrointestinal tract and 371 a primary nodal NHL. Histological specimens were reviewed by a panel of pathologists and classified according to the Kiel classification and the International Working Formulation. The 4-year survival rates for primary gastric, intestinal, other extranodal and nodal NHL ranged from 50 to 60%; the 4-year recurrence-free survival rates were 50%, 35%, 19% and 19%, respectively. Among patients with localised intermediate-grade disease survival for those with gastric NHL was better than for those with intestinal lymphoma. Because it is population-based, our study cohort was not subjected to exclusion due to age, performance scale, etc. and therefore provides a more realistic picture of the occurrence and presentation of as well as prognosis for lymphoma in the population.
在一项基于人群的580例非霍奇金淋巴瘤（NHL）患者登记研究中，54例患者患有原发性胃淋巴瘤，42例患有肠道淋巴瘤，113例患有原发性结外淋巴瘤，病变位于胃肠道以外的其他部位，371例患有原发性结内NHL。组织学标本由一组病理学家进行复查，并根据 Kiel 分类法和国际工作方案进行分类。原发性胃、肠道、其他结外和结内NHL的4年生存率在50%至60%之间；4年无复发生存率分别为50%、35%、19%和19%。在局限性中度疾病患者中，胃NHL患者的生存率高于肠道淋巴瘤患者。由于该研究基于人群，我们的研究队列未因年龄、体能状态等因素而被排除，因此能更真实地反映人群中淋巴瘤的发生、表现及预后情况。
