Jacobs A, Janowska-Wieczorek A, Caro J, Bowen D T, Lewis T
Department of Haematology, University of Wales College of Medicine, Cardiff, U.K.
Br J Haematol. 1989 Sep;73(1):36-9. doi: 10.1111/j.1365-2141.1989.tb00215.x.
Serum concentration of erythropoietin (Epo) has been measured by radioimmunoassay in 46 patients with myelodysplastic syndromes. There is an overall inverse relationship between the level of Epo and the degree of anaemia but a wide range of Epo response between patients with similar haemoglobin concentrations. No differences were found between the different FAB groups, but the highest Epo levels were found in those patients with erythroid hypoplasia in the bone marrow. It is suggested that the intensity of erythroid activity in the marrow, as well as the degree of anaemia, may be a factor determining serum Epo concentration.
已采用放射免疫分析法对46例骨髓增生异常综合征患者的血清促红细胞生成素（Epo）浓度进行了测定。Epo水平与贫血程度总体呈负相关，但血红蛋白浓度相似的患者之间Epo反应范围较广。不同FAB组之间未发现差异，但骨髓红系发育不全的患者Epo水平最高。提示骨髓红系活动强度以及贫血程度可能是决定血清Epo浓度的一个因素。
