Leschot N J, Wolf H, Van Prooijen-Knegt A C, van Asperen C J, Verjaal M, Schuring-Blom G H, Boer K, Kanhai H H, Christiaens G C
University of Amsterdam, Academic Medical Centre, The Netherlands.
Br J Obstet Gynaecol. 1989 Jun;96(6):663-70. doi: 10.1111/j.1471-0528.1989.tb03280.x.
First-trimester chorionic villus sampling (CVS) was performed in a series of 1250 pregnancies. The direct method of karyotyping was successful in 1205 (96.4%). Abnormal laboratory findings resulted in 60 terminations of pregnancy (4.8%). In addition, six unexpected balanced chromosome rearrangements were detected. False-positive cytogenetic findings occurred in 2.3%, comprising 22 with mosaicism confined to the trophoblast, and a further six non-mosaic false-positive discrepancies were detected, four after termination of pregnancy. The outcome of the first 1000 pregnancies is known in all but one. There were no false-negative findings. Of 947 pregnancies meant to be continued, 34 (3.6%) ended in pregnancy loss before 28 weeks gestation. However, obstetricians with an experience of over 150 procedures had a pregnancy loss of 1.3%.
对1250例妊娠进行了孕早期绒毛取样（CVS）。直接核型分析方法在1205例（96.4%）中成功。异常实验室结果导致60例妊娠终止（4.8%）。此外，检测到6例意外的平衡染色体重排。假阳性细胞遗传学结果发生率为2.3%，包括22例局限于滋养层的嵌合体，另外还检测到6例非嵌合性假阳性差异，其中4例发生在妊娠终止后。除1例之外，前1000例妊娠的结局均已知。无假阴性结果。在打算继续妊娠的947例中，34例（3.6%）在妊娠28周前流产。然而，有超过150例操作经验的产科医生的流产率为1.3%。
