Jahoda M G, Pijpers L, Reuss A, Los F J, Wladimiroff J W, Sachs E S
Department of Obstetrics and Gynecology, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
Prenat Diagn. 1989 Sep;9(9):621-8. doi: 10.1002/pd.1970090905.
Data from 1,550 consecutive pregnancies after first-trimester prenatal diagnosis by transcervical chorionic villus sampling (TC-CVS) are presented. The sampling efficacy was 97.8 per cent; the mean amount of collected villus tissue was 23 mg (range 5-100 mg). There were 97 affected fetuses, mainly (73.2 per cent) with a chromosomal abnormality or a male karyotype in carriers of X-linked disease. Pregnancy termination in these and four other women for social reasons resulted in 1449 continuing pregnancies. In these pregnancies, the fetal loss rate up to 28 weeks of gestation was 5.1 per cent with the highest loss rate (3.9 per cent) before 16 weeks. When relating this fetal loss rate to maternal age, this was 6.1 per cent in the advanced maternal age group (greater than or equal to 36 years) against 3.1 per cent in the younger age group. In 1,376 pregnancies continuing beyond 28 weeks, the perinatal mortality rate was 1.1 per cent; the percentage of non-genetic congenital anomalies was 0.9 per cent. The reproductive pattern of women at high genetic risk after CVS followed by pregnancy termination was evaluated. Within 12 months after the first CVS followed by pregnancy termination, 70 per cent of women again requested CVS in a subsequent pregnancy.
本文呈现了1550例经宫颈绒毛取样（TC-CVS）进行孕早期产前诊断后的连续妊娠数据。取样成功率为97.8%；收集的绒毛组织平均量为23毫克（范围5-100毫克）。有97例胎儿受影响，主要（73.2%）是患有染色体异常或X连锁疾病携带者的男性核型。这些妇女以及其他四名妇女因社会原因终止妊娠，导致1449例继续妊娠。在这些妊娠中，妊娠28周前的胎儿丢失率为5.1%，其中16周前丢失率最高（3.9%）。将该胎儿丢失率与母亲年龄相关联时，高龄母亲组（大于或等于36岁）为6.1%，而年轻年龄组为3.1%。在1376例妊娠持续超过28周的情况中，围产儿死亡率为1.1%；非遗传性先天性异常的百分比为0.9%。对经绒毛取样后因终止妊娠而处于高遗传风险的妇女的生殖模式进行了评估。在首次绒毛取样并终止妊娠后的12个月内，70%的妇女在随后的妊娠中再次要求进行绒毛取样。
