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HMGB1在肺部疾病中的新作用：益友还是敌人。

Emerging role of HMGB1 in lung diseases: friend or foe.

作者信息

Ding Junying, Cui Xuran, Liu Qingquan

机构信息

Beijing Key Lab of Basic Study on Traditional Chinese Medicine (TCM) Infectious Diseases, Beijing Research Institute of TCM, Beijing Hospital of TCM affiliated to Capital Medical University, Beijing, China.

出版信息

J Cell Mol Med. 2017 Jun;21(6):1046-1057. doi: 10.1111/jcmm.13048. Epub 2016 Dec 31.

DOI:10.1111/jcmm.13048
PMID:28039939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5431121/
Abstract

Lung diseases remain a serious problem for public health. The immune status of the body is considered to be the main influencing factor for the progression of lung diseases. HMGB1 (high-mobility group box 1) emerges as an important molecule of the body immune network. Accumulating data have demonstrated that HMGB1 is crucially implicated in lung diseases and acts as independent biomarker and therapeutic target for related lung diseases. This review provides an overview of updated understanding of HMGB1 structure, release styles, receptors and function. Furthermore, we discuss the potential role of HMGB1 in a variety of lung diseases. Further exploration of molecular mechanisms underlying the function of HMGB1 in lung diseases will provide novel preventive and therapeutic strategies for lung diseases.

摘要

肺部疾病仍然是公共卫生领域的一个严重问题。身体的免疫状态被认为是肺部疾病进展的主要影响因素。高迁移率族蛋白B1（HMGB1）作为机体免疫网络的一个重要分子而出现。越来越多的数据表明，HMGB1与肺部疾病密切相关，并作为相关肺部疾病的独立生物标志物和治疗靶点。本综述概述了对HMGB1结构、释放方式、受体和功能的最新认识。此外，我们还讨论了HMGB1在多种肺部疾病中的潜在作用。进一步探索HMGB1在肺部疾病中发挥作用的分子机制将为肺部疾病提供新的预防和治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/b74923f46aae/JCMM-21-1046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/3d6c93a8b507/JCMM-21-1046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/8d1bd471cea3/JCMM-21-1046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/28e6209ce425/JCMM-21-1046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/b74923f46aae/JCMM-21-1046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/3d6c93a8b507/JCMM-21-1046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/8d1bd471cea3/JCMM-21-1046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/28e6209ce425/JCMM-21-1046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f35/5431121/b74923f46aae/JCMM-21-1046-g004.jpg

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