Abdalla H I, Baber R J, Kirkland A, Leonard T, Studd J W
Lister Fertility and Endocrinology Centre, Lister Hospital, London.
Br J Obstet Gynaecol. 1989 Sep;96(9):1071-5. doi: 10.1111/j.1471-0528.1989.tb03383.x.
Twenty-nine women, mean age 36.3 (SD 5.5) years, with premature ovarian failure received donated ova on an ovum donation programme. Three had Turner's syndrome, four a surgical menopause, one a chemotherapy-induced menopause and 21 had idiopathic premature ovarian failure. All donated oocytes were fertilized with frozen-thawed spermatozoa from the recipient's partner, and the resulting zygotes were frozen until transfer had been arranged. Overall, 19 women had intrauterine embryo transfer (ET) and a mean of 2.7 (SD 0.9) embryos were transferred on 20 occasions; 10 women underwent zygote intrafallopian transfer (ZIFT) and a mean of 3.5 (SD 0.5) zygotes were transferred on 10 occasions. Both groups were matched for age. The pregnancy rate per transfer was 20% in the ET group and 40% in the ZIFT group. After excluding the 10 women in the ET group who had fewer than three embryos transferred, the pregnancy rates were similar in the two groups, 30% in the ET group and 40% in the ZIFT group. Cryopreserved embryos may be used for ovum donation to preserve anonymity and still show a high pregnancy rate of at least 30% per transfer.
29名平均年龄为36.3（标准差5.5）岁的卵巢早衰女性在卵子捐赠项目中接受了捐赠卵子。其中3人患有特纳综合征，4人因手术导致绝经，1人因化疗导致绝经，21人患有特发性卵巢早衰。所有捐赠的卵母细胞都与来自受赠者伴侣的冻融精子受精，产生的受精卵被冷冻，直到安排好移植。总体而言，19名女性进行了宫内胚胎移植（ET），平均每次移植2.7（标准差0.9）个胚胎，共进行了20次移植；10名女性进行了输卵管内合子移植（ZIFT），平均每次移植3.5（标准差0.5）个合子，共进行了10次移植。两组年龄匹配。ET组每次移植的妊娠率为20%，ZIFT组为40%。在排除ET组中移植胚胎少于3个的10名女性后，两组的妊娠率相似，ET组为30%，ZIFT组为40%。冷冻保存的胚胎可用于卵子捐赠以保护匿名性，并且每次移植仍显示出至少30%的高妊娠率。
