Vascular & Medicinal Research, Texas Heart Institute, 6770 Bertner Avenue, MC 2-255, Houston, TX 77030, USA; Department of Medical Biology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
Vascular & Medicinal Research, Texas Heart Institute, 6770 Bertner Avenue, MC 2-255, Houston, TX 77030, USA.
Trends Cardiovasc Med. 2017 May;27(4):239-246. doi: 10.1016/j.tcm.2016.11.002. Epub 2016 Nov 19.
Cardiovascular disease (CVD) is a health problem of great concern to both the public and medical authorities. Low-density lipoprotein (LDL) has been reported to play an important role in both the development and progression of CVD, but studies are underway to determine how LDL exerts its effects. In recent years, it has been found that LDL has several subfractions, each of which affects endothelial function differently; L5, the most electronegative fraction, has been shown to be unique in that it induces an atherogenic response. This review examines the current knowledge concerning the relationships between L5 and CVD and highlights the role of L5 in the pathophysiology of CVD, especially with regards to atherosclerosis.
心血管疾病（CVD）是公众和医疗当局都非常关注的健康问题。已经有报道称，低密度脂蛋白（LDL）在 CVD 的发展和进展中都起着重要作用，但仍在进行研究以确定 LDL 如何发挥其作用。近年来，人们发现 LDL 有几个亚组分，每个亚组分对内皮功能的影响都不同；其中最带负电荷的 L5 亚组分，具有独特的诱导动脉粥样硬化反应的作用。这篇综述检查了目前关于 L5 与 CVD 之间关系的知识，并强调了 L5 在 CVD 的病理生理学中的作用，特别是在动脉粥样硬化方面。
