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Dyslipidaemias in 2017: Atherogenic lipoproteins as treatment targets.

作者信息

Catapano Alberico L

机构信息

Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy; and IRCCS MultiMedica, Sesto S. Giovanni, Via Milanese 100, 20099 Milan, Italy.

出版信息

Nat Rev Cardiol. 2018 Jan 16;15(2):75-76. doi: 10.1038/nrcardio.2017.221.

DOI:10.1038/nrcardio.2017.221
PMID:29336436
Abstract
摘要

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Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above: Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational Follow-Up.男性原发性低密度脂蛋白胆固醇水平升高至 190mg/dL 或以上的心血管疾病一级预防中降低低密度脂蛋白胆固醇:来自 WOSCOPS(苏格兰西部冠状动脉预防研究)5 年随机试验和 20 年观察随访的分析。
Circulation. 2017 Nov 14;136(20):1878-1891. doi: 10.1161/CIRCULATIONAHA.117.027966. Epub 2017 Sep 6.
2
Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.PCSK9 抑制剂依洛尤单抗降低 LDL-胆固醇水平的临床疗效和安全性:FOURIER 试验的预先设定的次要分析。
Lancet. 2017 Oct 28;390(10106):1962-1971. doi: 10.1016/S0140-6736(17)32290-0. Epub 2017 Aug 28.
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N Engl J Med. 2017 Sep 28;377(13):1217-1227. doi: 10.1056/NEJMoa1706444. Epub 2017 Aug 28.
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Eur Heart J. 2017 Aug 21;38(32):2499-2507. doi: 10.1093/eurheartj/ehx260.
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