Shimizu Eisuke, Yamaguchi Takefumi, Yagi-Yaguchi Yukari, Dogru Murat, Satake Yoshiyuki, Tsubota Kazuo, Shimazaki Jun
Department of Ophthalmology, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Department of Ophthalmology, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Am J Ophthalmol. 2017 Mar;175:148-158. doi: 10.1016/j.ajo.2016.12.014. Epub 2016 Dec 28.
To characterize the corneal higher-order aberrations (HOAs) in eyes with Acanthamoeba keratitis (AK), bacterial keratitis (BK), and fungal keratitis (FK).
Retrospective consecutive case series.
This retrospective study includes 18 normal subjects and 63 eyes of 62 consecutive patients with corneal scarring due to AK (20 eyes), BK (35 eyes), and FK (8 eyes) from 2010 to 2016. HOAs of the anterior and posterior surfaces and the total cornea were analyzed by anterior segment optical coherence tomography. Corneal HOA patterns were assigned on the basis of corneal topography maps. Corneal opacity grading was assigned on the basis of slit-lamp examinations. We evaluated corneal HOAs, corneal opacity grading, and their correlation with visual acuity.
HOAs of the total cornea within a 4-mm diameter were significantly larger in eyes with infectious keratitis (AK, 1.15 ± 2.06 μm; BK, 0.91 ± 0.88 μm; FK, 1.39 ± 1.46 μm) compared with normal controls (0.09 ± 0.01 μm, all, P < .001). Asymmetric pattern was the most common topographic pattern (30% in AK, 51.4% in BK, and 37.5% in FK), followed by the protrusion patterns (10% in AK, 20% in BK, and 12.5% in FK). The visual acuity significantly correlated with HOAs (anterior surface: R = 0.764, P < .0001; posterior surface: R = 0.745, P < .0001; total cornea: R = 0.669, P < .0001).
Larger corneal HOAs in patients with infectious keratitis were associated with poorer visual acuity values. Asymmetric pattern was the most common topographic pattern in infectious keratitis.
对棘阿米巴角膜炎（AK）、细菌性角膜炎（BK）和真菌性角膜炎（FK）患者的角膜高阶像差（HOA）进行特征分析。
回顾性连续病例系列研究。
本回顾性研究纳入了18名正常受试者以及2010年至2016年间62例因AK（20只眼）、BK（35只眼）和FK（8只眼）导致角膜瘢痕的连续患者的63只眼。通过眼前节光学相干断层扫描分析前表面、后表面及整个角膜的HOA。根据角膜地形图确定角膜HOA模式。根据裂隙灯检查确定角膜混浊分级。我们评估了角膜HOA、角膜混浊分级及其与视力的相关性。
与正常对照组（0.09±0.01μm）相比，感染性角膜炎患者（AK为1.15±2.06μm；BK为0.91±0.88μm；FK为1.39±1.46μm）直径4mm范围内整个角膜的HOA明显更大（所有P<0.001）。非对称模式是最常见的地形图模式（AK中占30%，BK中占51.4%，FK中占37.5%），其次是突出模式（AK中占10%，BK中占20%，FK中占12.5%）。视力与HOA显著相关（前表面：R=0.764，P<0.0001；后表面：R=0.745，P<0.0001；整个角膜：R=0.669，P<0.0001）。
感染性角膜炎患者角膜HOA越大，视力越差。非对称模式是感染性角膜炎最常见的地形图模式。
