Wilczyńki S, Petelenz M, Florek-Wojciechowska M, Kulesza S, Brym Sz, Błońska-Fajfrowska B, Kruk D
Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Basic Biomedical Science, Kasztanowa Street 3, Sosnowiec 41-200, Poland.
Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Basic Biomedical Science, Kasztanowa Street 3, Sosnowiec 41-200, Poland.
J Pharm Biomed Anal. 2017 Feb 20;135:199-205. doi: 10.1016/j.jpba.2016.12.018. Epub 2016 Dec 23.
H spin-lattice Nuclear Magnetic Resonance (NMR) relaxometry, vibrational spectroscopy and Atomic Force Microscopy (AFM) have been applied to differentiate between original and counterfeit Viagra. The relaxation studies have been performed in a frequency range covering four orders of magnitude, from 4kHz to 40MHz. It has been shown that for the counterfeit product the relaxation is bi-exponential in the whole frequency range, while for the original Viagra the relaxation process is always single exponential. Thus, even a qualitative analysis of the relaxation data makes it possible to identify the falsified medicine. Moreover, it has been demonstrated that vibrational spectroscopy does not allow for differentiating between the products, while AFM studies are likely to lead one to deceptive conclusions regarding the originality of the medicine. Furthermore, a quantitative analysis of the relaxation data has been performed to describe in detail the relaxation properties of the original and falsified products.
氢自旋晶格核磁共振（NMR）弛豫测量法、振动光谱法和原子力显微镜（AFM）已被用于区分正品和假冒伟哥。弛豫研究是在覆盖四个数量级的频率范围内进行的，从4kHz到40MHz。结果表明，对于假冒产品，弛豫在整个频率范围内是双指数的，而对于正品伟哥，弛豫过程始终是单指数的。因此，即使对弛豫数据进行定性分析也能够识别出假药。此外，已经证明振动光谱法无法区分这些产品，而AFM研究可能会导致人们对药品的真伪得出误导性结论。此外，还对弛豫数据进行了定量分析，以详细描述正品和假冒产品的弛豫特性。
