Sartorelli L, Mantovani G, Ciman M
Dipartimento di Chimica Biologica, CNR, Padova, Italy.
Biochim Biophys Acta. 1989 Nov 6;1006(1):15-8. doi: 10.1016/0005-2760(89)90317-2.
Administration of L-carnitine to rats was followed by an increase of deoxycarnitine in urine. Conversely, administration of deoxycarnitine caused an increase of carnitine. The latter treatment also produced a transient but significant diminution of L-carnitine in heart, skeletal muscle and kidney, but not in liver and plasma. Administration of D-carnitine to rats previously loaded with deoxycarnitine significantly depleted the elevated deoxycarnitine concentration in skeletal muscle and kidney while increasing it in plasma. These results suggest that the tissue exchange between L-carnitine and deoxycarnitine, already demonstrated in vitro, occurs also in vivo.
给大鼠注射左旋肉碱后，其尿液中的脱氧肉碱增加。相反，注射脱氧肉碱会导致肉碱增加。后一种处理还使心脏、骨骼肌和肾脏中的左旋肉碱短暂但显著减少，但肝脏和血浆中没有。给预先注射了脱氧肉碱的大鼠注射D-肉碱，可显著降低骨骼肌和肾脏中升高的脱氧肉碱浓度，同时使血浆中的脱氧肉碱浓度升高。这些结果表明，左旋肉碱和脱氧肉碱之间的组织交换，已在体外得到证实，在体内也会发生。
