Grimstad Tore, Skoie Inger Marie, Doerner Jessica, Isaksen Kjetil, Karlsen Lars, Aabakken Lars, Omdal Roald, Putterman Chaim
a Department of Internal Medicine , Stavanger University Hospital , Stavanger , Norway.
b Department of Dermatology , Stavanger University Hospital , Stavanger , Norway.
Scand J Gastroenterol. 2017 Apr;52(4):420-424. doi: 10.1080/00365521.2016.1273382. Epub 2016 Dec 31.
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) may be involved in the pathogenesis of inflammatory bowel disease. The aim was to investigate if TWEAK may reflect disease activity in inflammatory bowel disease.
In this cohort study, 139 consecutive patients with newly diagnosed and previously untreated inflammatory bowel disease - 95 with ulcerative colitis (UC) and 44 with Crohn's disease (CD) - underwent colonoscopy. Disease activity was assessed by the Mayo score and the Mayo endoscopic score (MES) for UC, or the Simple Endoscopic Score (SES) for CD. Serum C-reactive protein (CRP) and fecal calprotectin were measured in IBD patients, as were plasma TWEAK levels in patients and 85 healthy subjects. Associations between TWEAK levels and disease activity markers were explored.
In the total IBD group, the median (interquartile range) TWEAK level was 430 pg/ml (109-6570), in UC 502 pg/ml (109-4547) and in CD patients 352 pg/ml (101-9179), respectively. Healthy subjects had a median (IQR) TWEAK of 307 pg/ml (63-3492). There were no significant differences in TWEAK levels between the total IBD group and healthy control subjects, nor between UC and CD, or between UC/CD and healthy subjects. Furthermore, we found no significant associations between Mayo scores, MES-UC, SES-CD, CRP, and fecal calprotectin with plasma TWEAK levels.
Plasma TWEAK levels do not reflect disease activity or the grade of inflammation in patients with newly diagnosed inflammatory bowel disease. NCT01551563.
肿瘤坏死因子样凋亡微弱诱导剂（TWEAK）可能参与炎症性肠病的发病机制。本研究旨在探讨TWEAK是否可反映炎症性肠病的疾病活动度。
在这项队列研究中，139例新诊断且未经治疗的炎症性肠病患者——95例溃疡性结肠炎（UC）患者和44例克罗恩病（CD）患者——接受了结肠镜检查。通过Mayo评分和Mayo内镜评分（MES）评估UC患者的疾病活动度，或通过简易内镜评分（SES）评估CD患者的疾病活动度。检测了炎症性肠病患者的血清C反应蛋白（CRP）和粪便钙卫蛋白，以及患者和85名健康受试者的血浆TWEAK水平。探讨了TWEAK水平与疾病活动度标志物之间的关联。
在整个炎症性肠病组中，TWEAK水平的中位数（四分位间距）为430 pg/ml（109 - 6570），UC患者为502 pg/ml（109 - 4547），CD患者为352 pg/ml（101 - 9179）。健康受试者的TWEAK中位数（IQR）为307 pg/ml（63 - 3492）。整个炎症性肠病组与健康对照受试者之间、UC与CD之间、UC/CD与健康受试者之间的TWEAK水平均无显著差异。此外，我们发现Mayo评分、MES-UC、SES-CD、CRP和粪便钙卫蛋白与血浆TWEAK水平之间均无显著关联。
血浆TWEAK水平不能反映新诊断的炎症性肠病患者的疾病活动度或炎症程度。NCT01551563。
