Schmidt Morten, Fosbøl Emil Loldrup, Torp-Pedersen Christian, Olsen Anne-Marie Schjerning, Christensen Bo, Gislason Gunnar H
Ugeskr Laeger. 2016 Dec 26;178(52).
Non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs. Current evidence supports that all NSAIDs increase the risk of heart failure and elevate blood pressure, whereas the risk of thrombotic events varies with the type of drug. Use of newer selective cyclooxygenase-2 inhibitors has been associated with a substantial vascular risk but increasing concern also relates to traditional NSAIDs, in particular diclofenac. This review summarizes the current evidence regarding the cardiovascular safety of NSAIDs and presents recommendations for their use.
非阿司匹林类非甾体抗炎药（NSAIDs）是使用最为广泛的药物之一。目前的证据表明，所有NSAIDs都会增加心力衰竭风险并升高血压，而血栓形成事件的风险则因药物类型而异。新型选择性环氧化酶-2抑制剂的使用与重大血管风险相关，但人们对传统NSAIDs，尤其是双氯芬酸的担忧也在增加。本综述总结了有关NSAIDs心血管安全性的当前证据，并提出了使用建议。
