[Centrosome behavior in the exposure of tissue culture cells to energy metabolism inhibitors].

The organization of the centrosome in PK cells has been analysed according to several parameters: the presence of primary cilium, the number of pericentriolar satellites, the presence of striated rootlets, the distance between two centrioles and their orientation as regards the substrate plane. 2,4-Dinitrophenol (DNP), DNP with deoxyglucose (DOG), sodium azide cause the increase of frequency of occurrence of primary cilia and the growth of mean number of satellites per active centriole. The distribution of active and inactive centrioles in control cells is described by a histogram corresponding to a histogram of accidental distribution. Under the action of DNP or DNP with DOG, but not of sodium azide a part of active centrioles settled down perpendicularly to the substrate plane increases. The orientation of inactive centrioles under all the treatments used doesn't practically change.