患有血管风险的双相情感障碍患者在抑制能力方面呈现出与年龄相关的更陡峭负斜率，但处理速度方面则不然：一项初步研究。
Bipolar Patients with Vascular Risk Display a Steeper Age-Related Negative Slope in Inhibitory Performance but Not Processing Speed: A Preliminary Study.
作者信息
Dev Sheena I, Eyler Lisa T
机构信息
Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA; Department of Psychiatry, University of California, La Jolla, San Diego, CA; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA.
Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA; Department of Psychiatry, University of California, La Jolla, San Diego, CA; San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA.
出版信息
Am J Geriatr Psychiatry. 2017 Mar;25(3):272-276. doi: 10.1016/j.jagp.2016.12.002. Epub 2016 Dec 7.
OBJECTIVE
Bipolar disorder (BD) is associated with cognitive deficits, yet little is known about associations between cognition, vascular risk (VR), and age in this population. This study investigated whether BD patients with VR demonstrate stronger apparent age-related decline in inhibitory performance and processing speed (PS).
METHODS
A full medical history was obtained for 34 euthymic BD and 41 healthy comparison (HC) individuals. The Delis-Kaplan Executive Functions Color Word Interference Subtests were administered to all participants to assess for inhibitory performance (condition 3) and PS (conditions 1 and 2). VR positive (VRPos) and VR negative (VRNeg) groups were created based on the presence of one or more VR factors.
RESULTS
VRPos-BD participants demonstrated significantly worse inhibitory performance with older age, whereas age and inhibition were not significantly related in the VRPos-HC group or in those who were VRNeg. The same was not true for PS.
CONCLUSION
BD patients with VR may also be at risk for greater decline in inhibitory performance, but not PS, with age. Longitudinal studies are needed to further investigate the contributions of VR to cognitive decline among older BD patients.
目的
双相情感障碍（BD）与认知缺陷相关，但对于该人群中认知、血管风险（VR）和年龄之间的关联却知之甚少。本研究调查了患有VR的BD患者在抑制能力和处理速度（PS）方面是否表现出更强的与年龄相关的明显衰退。
方法
获取了34名心境正常的BD患者和41名健康对照（HC）个体的完整病史。对所有参与者进行了德利斯-卡普兰执行功能颜色词干扰子测试，以评估抑制能力（条件3）和PS（条件1和2）。根据是否存在一种或多种VR因素，将患者分为VR阳性（VRPos）组和VR阴性（VRNeg）组。
结果
VRPos-BD参与者随着年龄增长，抑制能力显著变差，而在VRPos-HC组或VRNeg组中，年龄与抑制能力之间无显著相关性。PS方面则并非如此。
结论
患有VR的BD患者可能也面临着随着年龄增长抑制能力下降加剧的风险，但PS并非如此。需要进行纵向研究以进一步调查VR对老年BD患者认知衰退的影响。
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