Dev Sheena I, Nguyen Tanya T, McKenna Benjamin S, Sutherland Ashley N, Bartsch Hauke, Theilmann Rebecca J, Eyler Lisa T
Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA; Departments of Psychiatry, University of California, San Diego, CA; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA.
Mental Illness Research, Education, and Clinical Center, Veterans Affairs San Diego Healthcare System, San Diego, CA; Departments of Psychiatry, University of California, San Diego, CA.
Am J Geriatr Psychiatry. 2017 Jul;25(7):744-752. doi: 10.1016/j.jagp.2017.02.014. Epub 2017 Feb 16.
Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging.
Cross-sectional study.
University of California San Diego and the Veterans Administration San Diego Healthcare System.
33 euthymic BD and 38 HC participants.
Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test.
BD participants demonstrated slower PS compared with the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum, and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently.
Results provide support for future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD.
双相情感障碍（BD）与白质（WM）完整性受损和处理速度（PS）缺陷有关。然而，很少有研究调查年龄与WM结构和认知的关系，以了解大脑健康在整个生命周期中可能发生的变化。本研究探讨了BD患者和健康对照（HC）参与者在与WM和认知相关的年龄关联上是否存在差异，这可能提示大脑和认知加速老化。
横断面研究。
加利福尼亚大学圣地亚哥分校和圣地亚哥退伍军人事务医疗系统。
33名病情稳定的BD患者和38名HC参与者。
采用扩散张量成像来测量WM完整性，并利用约翰霍普金斯大学概率图谱提取特定脑区的分数各向异性（FA）。使用Delis-Kaplan执行功能系统连线测验的数字和字母序列条件评估PS。
与HC组相比，BD患者的PS较慢，但各脑区的FA在两组间未发现差异。多元线性回归显示，右侧钩束、扣带束左侧海马部分以及PS存在显著的组×年龄交互作用，即仅在BD组中，年龄较大与较低的FA值和较慢的PS相关。在考虑钩束FA后，年龄与PS之间的关系没有显著变化，这表明观察到的年龄关联是独立发生的。
通过识别在BD中显示出不同年龄关联的大脑健康标志物，本研究结果为加速老化假说的未来研究提供了支持。
