Jesulola Emmanuel, Sharpley Christopher F, Agnew Linda L
Brain-Behaviour Research Group, University of New England, Queen Elizabeth Drive, Armidale, New South Wales, 2351, Australia.
Brain-Behaviour Research Group, University of New England, Queen Elizabeth Drive, Armidale, New South Wales, 2351, Australia.
Behav Brain Res. 2017 Mar 15;321:232-239. doi: 10.1016/j.bbr.2016.12.035. Epub 2016 Dec 29.
Data describing the association between EEG asymmetry and depression status have been equivocal. Effects from brain regions involved, depression severity, and the generalisability of findings across genders, have been inconsistently examined and/or verified. This study investigated these issues within a community sample to potentially expand the asymmetry hypothesis to non-severe depression participants. The singular effects of brain region and electrode site, gender, and depression severity, plus the interaction between gender and depression severity across brain regions were investigated in a study of alpha asymmetry among 46 males and 54 females (M age=32.5 yr, SD=14.13 yr) using the Self-rating Depression Scale (Zung, 1973). There was no significant difference across genders or age for depression severity. Dichotomous classification of depressed state produced similar but slightly different results from analysis of the whole range of depression status, although the frontal region was the only area where depression was consistently significantly associated with EEG asymmetry, and then only for females. However, the direction of those differences for females was opposite of that predicted by the EEG asymmetry-depression hypothesis. Several methodological issues that may have contributed to these findings are discussed, with suggestions made for future research that focusses upon individual depression symptom profiles rather than dichotomous or total depression scores in order to assist in developing a clinically-relevant model of EEG asymmetry in depressed persons.
描述脑电图不对称性与抑郁状态之间关联的数据一直不明确。涉及的脑区、抑郁严重程度以及研究结果在不同性别中的普遍性所产生的影响，尚未得到一致的研究和/或验证。本研究在一个社区样本中调查了这些问题，以潜在地将不对称性假设扩展到非重度抑郁参与者。在一项针对46名男性和54名女性（平均年龄 = 32.5岁，标准差 = 14.13岁）的α波不对称性研究中，使用自评抑郁量表（Zung，1973），研究了脑区和电极部位、性别以及抑郁严重程度的单一影响，以及不同脑区中性别与抑郁严重程度之间的相互作用。抑郁严重程度在不同性别或年龄之间没有显著差异。抑郁状态的二分法分类与对整个抑郁状态范围的分析产生了相似但略有不同的结果，尽管额叶区域是唯一与脑电图不对称性始终存在显著关联的区域，且仅针对女性。然而，女性的这些差异方向与脑电图不对称性 - 抑郁假设所预测的相反。讨论了可能导致这些结果的几个方法学问题，并对未来研究提出了建议，即关注个体抑郁症状特征而非二分法或总抑郁得分，以协助建立一个与抑郁症患者脑电图不对称性相关的临床模型。
