抑郁症行为激活治疗前后的额叶脑电图α波不对称性
Frontal alpha EEG asymmetry before and after behavioral activation treatment for depression.
作者信息
Gollan Jackie K, Hoxha Denada, Chihade Dietta, Pflieger Mark E, Rosebrock Laina, Cacioppo John
机构信息
Northwestern University Feinberg School of Medicine, Asher Center for the Study and Treatment of Depressive Disorders, 676 North St. Clair Street, Chicago, IL 60611, USA.
Northwestern University Feinberg School of Medicine, Asher Center for the Study and Treatment of Depressive Disorders, 676 North St. Clair Street, Chicago, IL 60611, USA.
出版信息
Biol Psychol. 2014 May;99:198-208. doi: 10.1016/j.biopsycho.2014.03.003. Epub 2014 Mar 24.
BACKGROUND
Mid-frontal and mid-lateral (F3/F4 and F7/F8) EEG asymmetry has been associated with motivation and affect. We examined alpha EEG asymmetry in depressed and healthy participants before and after Behavioral Activation treatment for depression; examined the association between alpha EEG asymmetry and motivational systems and affect; and evaluated the utility of alpha EEG asymmetry in predicting remission.
METHODS
Depressed (n=37) and healthy participants (n=35) were assessed before and after treatment using a clinical interview, a task to measure baseline EEG, and questionnaires of behavioral activation and inhibition, avoidance, and affect.
RESULTS
Alpha EEG asymmetry was significantly higher in depressed than healthy participants at pre-treatment, positively correlated with negative affect and behavioral inhibition, and inversely correlated with lower behavioral activation sensitivity.
CONCLUSIONS
Heightened alpha EEG asymmetry in depressed participants was significantly associated with increased behavioral inhibition and negative emotion and was independent of clinical remission.
背景
额中部和外侧中部（F3/F4和F7/F8）脑电图不对称性与动机和情感有关。我们在对抑郁症患者进行行为激活治疗前后，研究了抑郁症患者和健康参与者的脑电图α波不对称性；研究了脑电图α波不对称性与动机系统和情感之间的关联；并评估了脑电图α波不对称性在预测缓解方面的效用。
方法
使用临床访谈、测量基线脑电图的任务以及行为激活与抑制、回避和情感问卷，在治疗前后对抑郁症患者（n = 37）和健康参与者（n = 35）进行评估。
结果
治疗前，抑郁症患者的脑电图α波不对称性显著高于健康参与者，与负面情绪和行为抑制呈正相关，与较低的行为激活敏感性呈负相关。
结论
抑郁症患者脑电图α波不对称性增强与行为抑制增加和负面情绪显著相关，且与临床缓解无关。
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