Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
J Psychiatr Res. 2024 Sep;177:97-101. doi: 10.1016/j.jpsychires.2024.06.051. Epub 2024 Jul 2.
Anhedonia, a transdiagnostic symptom present in many neuropsychiatric disorders, differs in males and females. Parietal EEG alpha asymmetry is associated with reduced arousal and low positive emotionality, and is, therefore, a promising neurophysiologic biomarker of anhedonia. To date, however, no prior studies have determined whether this measure captures sex differences in anhedonic expression. This preliminary study (N = 36) investigated whether anhedonia severity is associated with EEG resting-state parietal alpha asymmetry in adults and whether sex moderates this relationship. Results showed that there was a significant moderating effect of sex such that, only for females, higher levels of anhedonia were associated with increased parietal alpha asymmetry. These findings suggest that parietal alpha asymmetry is a promising biomarker of anhedonia severity in female adults and reinforces the need to account for sex differences in future research.
快感缺失，一种存在于许多神经精神疾病中的跨诊断症状，在男性和女性中有所不同。顶叶 EEG 阿尔法不对称性与唤醒减少和低正性情绪有关，因此是快感缺失的有前途的神经生理生物标志物。然而，迄今为止，尚无先前的研究确定该测量是否可以捕捉快感缺失表达的性别差异。这项初步研究（N=36）调查了快感缺失严重程度是否与成年人的 EEG 静息状态顶叶阿尔法不对称性相关，以及性别是否调节这种关系。结果表明，性别存在显著的调节作用，即只有女性，较高水平的快感缺失与顶叶阿尔法不对称性增加相关。这些发现表明，顶叶阿尔法不对称性是女性成年人快感缺失严重程度的一个有前途的生物标志物，并强调在未来的研究中需要考虑性别差异。
