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长春氟宁治疗晚期尿路上皮癌：临床证据与经验

Vinflunine in the treatment of advanced urothelial cancer: clinical evidence and experience.

作者信息

Gerullis Holger, Wawroschek Friedhelm, Köhne Claus-Henning, Ecke Thorsten Holger

机构信息

University Hospital for Urology, Klinikum Oldenburg, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Rahel-Straus-Straße 10, 26133 Oldenburg, Germany.

University Hospital for Urology, Klinikum Oldenburg, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Germany.

出版信息

Ther Adv Urol. 2017 Jan;9(1):28-35. doi: 10.1177/1756287216677903. Epub 2016 Nov 21.

DOI:10.1177/1756287216677903
PMID:28042310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5167074/
Abstract

Vinflunine (VFL) has been approved in Europe for second-line treatment of metastatic and advanced urothelial cancer after failure of platin-containing therapy. Since approval, the drug has been investigated in few clinical trials. Most of the currently available reports describe experiences with VFL in a daily clinical setting. This review gives a short overview on clinical experiences and clinical trials involving VFL since the approval of this drug in 2009.

摘要

长春氟宁（VFL）已在欧洲获批用于含铂疗法失败后的转移性和晚期尿路上皮癌的二线治疗。自获批以来，该药物仅在少数临床试验中进行了研究。目前大多数现有报告描述了VFL在日常临床环境中的应用经验。本综述简要概述了自2009年该药物获批以来涉及VFL的临床经验和临床试验。

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Efficacy and safety of Vinflunine for advanced or metastatic urothelial carcinoma in routine practice based on the French multi-centre CURVE study.基于法国多中心CURVE研究，长春氟宁在晚期或转移性尿路上皮癌常规治疗中的疗效与安全性。
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Docetaxel As Monotherapy or Combined With Ramucirumab or Icrucumab in Second-Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma: An Open-Label, Three-Arm, Randomized Controlled Phase II Trial.多西他赛单药或联合雷莫芦单抗或伊立替康治疗局部晚期或转移性尿路上皮癌的二线治疗：一项开放标签、三臂、随机对照的 II 期试验。
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[Study on therapy of metastasized or locally advanced urothelial cancer: A phase III randomized clinical trial of pembrolizumab (MK-3475) versus paclitaxel, docetaxel or vinflunine in subjects with recurrent or progressive metastatic urothelial cancer (Keynote 045) - AP 48/15 der AUO].转移性或局部晚期尿路上皮癌的治疗研究：帕博利珠单抗（MK-3475）与紫杉醇、多西他赛或长春氟宁治疗复发性或进展性转移性尿路上皮癌受试者的III期随机临床试验（KEYNOTE-045）——AUO的AP 48/15
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