高山槐黄酮通过调节miR-370/PIM1信号通路诱导食管鳞状细胞癌凋亡。
Alpinumisoflavone induces apoptosis in esophageal squamous cell carcinoma by modulating miR-370/PIM1 signaling.
作者信息
Han Yantao, Yang Xiuwei, Zhao Ning, Peng Jianjun, Gao Hui, Qiu Xia
机构信息
Qingdao University Qingdao 266071, Shandong, China.
Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
出版信息
Am J Cancer Res. 2016 Dec 1;6(12):2755-2771. eCollection 2016.
Abstract
Esophageal squamous cell carcinoma (ESCC) is the most prevalent type of esophageal cancer and accumulating evidence has confirmed the role of miRNAs in ESCC. One such miRNA, miR-370, was found to be aberrantly downregulated in various human malignancies. This study showed that the expression of miR-370 was significantly lower in ESCC tissues and cell lines, and miR-370 functioned as a tumor suppressor in ESCC. Moreover, this is the first report that showed miR-370 suppresses cell proliferation and tumor growth by directly targeting Pim family kinases 1 (PIM1). Furthermore, alpinumisoflavone, a naturally occurring flavonoid, could inhibit tumor growth of ESCC by targeting miR-370/PIM1 signaling.
摘要
食管鳞状细胞癌（ESCC）是食管癌最常见的类型，越来越多的证据证实了微小RNA（miRNA）在ESCC中的作用。其中一种miRNA，即miR-370，被发现在各种人类恶性肿瘤中异常下调。本研究表明，miR-370在ESCC组织和细胞系中的表达显著降低，且miR-370在ESCC中发挥肿瘤抑制作用。此外，这是首次报道miR-370通过直接靶向Pim家族激酶1（PIM1）来抑制细胞增殖和肿瘤生长。此外，高山槐黄素，一种天然存在的黄酮类化合物，可通过靶向miR-370/PIM1信号通路抑制ESCC的肿瘤生长。
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