Mendieta J, Herráez A, Sancho P, Luque J
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Madrid, Spain.
Biosci Rep. 1989 Oct;9(5):541-8. doi: 10.1007/BF01119796.
A decrease in the number of binding sites for 125I-transferrin, without an apparent modification of the association constant, has been observed during the maturation of reticulocytes into erythrocytes. As an experimental model, different red cell populations from phenylhydrazinic anaemic rates (95% to 12% reticulocyte-rich) have been used. The fractionation by multiple partition in two-phase systems of these red cell populations has been applied here to show the relationship between number of transferrin receptors and rate of reticulocyte maturation.
在网织红细胞成熟为红细胞的过程中，已观察到125I-转铁蛋白结合位点数量减少，而结合常数无明显改变。作为实验模型，使用了来自苯肼贫血大鼠的不同红细胞群体（网织红细胞丰富度为95%至12%）。在此应用两阶段系统中多步分配法对这些红细胞群体进行分级分离，以显示转铁蛋白受体数量与网织红细胞成熟速率之间的关系。
