Ni Qingwen, Dixon Hong, Gutierrez Gloria, Bi Long, Qin Yi-Xian
Southwest Research Institute, San Antonio, TX, USA; Texas A&M International University, Laredo, TX, USA.
Southwest Research Institute, San Antonio, TX, USA.
Adv Biosci Bioeng (N Y). 2013 Jun;1(1):1-7. doi: 10.11648/j.abb.20130101.11. Epub 2014 Jun 14.
A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model.
已合成具有所需释放速率的纳米封装（+）异丙嗪对映体配方，以建立局部给药系统。在大鼠后肢悬吊（HLS）废用模型上进行了测试，并使用无损核磁共振（NMR）弛豫技术和微型计算机断层扫描（Micro-CT）分析技术，定性评估新骨形成的有效性，并比较当前市售的抗骨质流失药物阿仑膦酸盐。我们的研究表明，在控释制剂中结合骨靶向官能团的纳米封装（+）异丙嗪可有效促进废用大鼠模型中的骨生长。
