Koskas Pierre, Henry-Feugeas Marie Cecile, Feugeas Jean-Paul, Ou Phalla, Drunat Olivier
Memory Center, Bretonneau Hospital, Assistance Publique-Hôpitaux de Paris, 23 rue Joseph de Maistre 75018 Paris, France.
Department of Radiology, Bichat Claude Bernard University Hospital, Assistance Publique- Hôpitaux de Paris, 46 rue Henri Huchard, Paris, France.
Curr Aging Sci. 2017;10(2):129-135. doi: 10.2174/1874609810666170102143257.
Rapid Cognitive Decline (RCD) in Alzheimer's Disease (AD) is associated with a worse disease progression. There is no consensual predictor of RCD and only a few studies have focused on RCD in late-onset dementia, the most common form of AD.
To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD.
Community-dwelling subjects aged >75 consulting for the first time in Old Age Memory outpatient center from 2009 to 2012 were considered. All patients underwent a standardized clinical dementia investigation. Patients were classified as rapid decliners when they demonstrated a loss of 3 points or greater in MMSE during the first six months.
130 patients were included (42 males, 88 females, mean ages 82.7±4.58). The average baseline MMSE score was 23.36±3.78. In regression analysis, the Free Recall Scores, categorical fluency scores were the most highly predictive of RCD.
These results are important for the design of clinical trials and also, in clinical practice, for both physicians and families in planning long-term care.
阿尔茨海默病（AD）中的快速认知衰退（RCD）与更差的疾病进展相关。目前尚无关于RCD的共识性预测指标，仅有少数研究关注晚发性痴呆（AD最常见的形式）中的RCD。
在近期诊断为晚发性AD的社区居住患者群体中确定RCD的预测指标。
纳入2009年至2012年首次在老年记忆门诊中心就诊的75岁以上社区居住受试者。所有患者均接受标准化临床痴呆症调查。在最初六个月内简易精神状态检查表（MMSE）评分下降3分或更多的患者被归类为快速衰退者。
纳入130例患者（42例男性，88例女性，平均年龄82.7±4.58岁）。平均基线MMSE评分为23.36±3.78。在回归分析中，自由回忆得分、分类流畅性得分对RCD的预测性最高。
这些结果对于临床试验设计很重要，在临床实践中，对医生和家庭规划长期护理也很重要。
