Zhang Hengdong, Xu Ming, Zhao Qiuni, Sun Kai, Gong Wei, Zhang Qiaoyun, Zhu Baoli, An Yan
Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China.
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention and Control, Nanjing 210028, China.
Int J Environ Res Public Health. 2016 Dec 31;14(1):36. doi: 10.3390/ijerph14010036.
Lead () is one of the major contaminants in many industries, and imposes hazardous effects on multiple human organs and systems. Studies have shown that lead is able to induce the alteration of microRNA (miRNA) expression in serum and organs. In this study we investigated whether polymorphisms in miRNA-regulating genes were associated with the risk of lead exposure. We genotyped seven single-nucleotide polymorphisms (SNPs) in 113 lead-sensitive and 113 lead-resistant lead-related Chinese workers by Taqman analysis. The lead-sensitive group showed a significantly higher blood lead level (BLL) than the resistant group based on unconditional logistic regression results. One SNP in extron (rs2257082) was significantly associated with lead-poisoning ( = 0.022, odds rate (OR) = 1.63, 95% confidence interval (CI) = 1.07-2.47 in the C allele compared to the T allele). There were no significant associations between the other six SNPs and the blood lead levels. Therefore, polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations, and to develop more specific and accurate preventions.
铅是许多行业中的主要污染物之一，会对人体多个器官和系统产生有害影响。研究表明，铅能够诱导血清和器官中微小RNA（miRNA）表达的改变。在本研究中，我们调查了miRNA调控基因中的多态性是否与铅暴露风险相关。我们通过Taqman分析对113名对铅敏感和113名对铅耐受的中国铅相关工人中的7个单核苷酸多态性（SNP）进行了基因分型。基于无条件逻辑回归结果，铅敏感组的血铅水平（BLL）显著高于耐受组。外显子中的一个SNP（rs2257082）与铅中毒显著相关（与T等位基因相比，C等位基因的P = 0.022，优势比（OR） = 1.63，95%置信区间（CI） = 1.07 - 2.47）。其他六个SNP与血铅水平之间无显著关联。因此，多态性rs2257082可用于区分铅耐受和铅敏感人群，并制定更具体、准确的预防措施。
