Sanders Alison P, Burris Heather H, Just Allan C, Motta Valeria, Amarasiriwardena Chitra, Svensson Katherine, Oken Emily, Solano-Gonzalez Maritsa, Mercado-Garcia Adriana, Pantic Ivan, Schwartz Joel, Tellez-Rojo Martha M, Baccarelli Andrea A, Wright Robert O
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Neonatology, Beth Israel Deaconess Medical Center & Division of Newborn Medicine, Boston Children's Hospital & Harvard Medical School, 330 Brookline Ave, RO 318, Boston, MA 02215, USA.
Epigenomics. 2015;7(6):885-96. doi: 10.2217/epi.15.54. Epub 2015 Sep 29.
Toxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels.
MATERIALS & METHODS: We obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates.
Seventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286.
The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.
包括铅和汞在内的有毒金属与不良妊娠结局相关。本研究旨在评估孕期宫颈中微小RNA（miRNA）表达与铅和汞水平之间的关联。
我们从孕妇（n = 60）处获取宫颈拭子，并对宫颈miRNA表达进行定量。分析了女性的血铅、骨铅和趾甲汞水平。我们进行线性回归，以检验在调整协变量后金属水平与74种miRNA表达之间的关联。
17种miRNA与趾甲汞水平呈负相关，胫骨骨铅水平与miR-575和miR-4286表达降低有关。
这些发现突出了人类宫颈中的miRNA是孕期母体化学暴露的新型反应者。
